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Recurrent Implantation Failure

Recurrent Implantation Failure (RIF) can be a challenging and frustrating experience, generally defined as the failure to achieve a clinical pregnancy after transferring several good-quality embryos in multiple IVF cycles.

Causes of Recurrent Implantation Failure

RIF can be caused by various factors, including:

  • Embryonic Factors:

    • Genetic abnormalities in the embryo

    • Poor embryo quality

  • Uterine Factors:

    • Endometrial receptivity issues

    • Uterine abnormalities (e.g., fibroids, polyps)

    • Chronic endometritis

  • Immune Factors:

    • Abnormal immune responses affecting implantation

Diagnosis of Recurrent Implantation Failure

At MMC IVF, we diagnose RIF after a thorough evaluation to identify potential underlying causes. We use methods like:

  • Genetic Testing:

    • Preimplantation Genetic Testing (PGT) for embryos

    • Karyotyping of both partners

  • Uterine Assessment:

    • Transvaginal ultrasound

    • Hysteroscopy

    • Endometrial biopsy

  • Immune Profiling:

    • Blood tests for autoimmune disorders

    • Uterine Natural Killer (UNK) cell testing

Treatment Options for Recurrent Implantation Failure

Addressing RIF requires a personalized approach based on the identified causes. Here are some options MMC IVF offers:

  • Optimizing Embryo Quality:

    • Use of donor eggs or sperm if genetic issues are detected

    • Advanced embryo culture techniques

  • Enhancing Uterine Environment:

    • Surgical correction of uterine abnormalities

    • Treatment of endometrial infections or inflammation

  • Immunotherapy:

    • Steroids or other immune-modulating treatments if immune factors are involved

  • Adjunct Therapies:

    • Acupuncture

    • Lifestyle modifications to reduce stress

Talk to our expert

Recurrent Implantation Failure can be daunting to those couples who have yet to achieve successful pregnancies. With our expert team led by Dr. Srisailesh Vitthala, a Royal College Accredited specialist in Reproductive Medicine and Consultant Gynaecologist, MMC IVF offers world-class infertility services. 

Ready to take next step?

Schedule a consultation with our expert team at MMC IVF. We are here to provide personalized care and support

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